|
|
H2O + acetoacetyl-CoA <=> H+ + acetoacetate + CoA
|
3.1.2.1
acetyl-CoA hydrolase
3.1.2.11
acetoacetyl-CoA hydrolase
3.1.2.18
ADP-dependent short-chain-acyl-CoA hydrolase
3.1.2.32
2-aminobenzoylacetyl-CoA thioesterase
|
–
–
–
–
|
MK
|
|
BRENDA:
BR10671
KEGG:
R01358
MetaCyc:
ACETOACETYL-COA-HYDROLASE-RXN
|
|
|
|
(R)-3-hydroxybutanoate + NAD+ <=> acetoacetate + NADH + H+
|
1.1.1.30
3-hydroxybutyrate dehydrogenase
|
–
|
MK
|
|
BRENDA:
BR29293
KEGG:
R01361
MetaCyc:
3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN
SABIO-RK:
1565
|
|
|
|
L-3-hydroxybutyrate + 2-oxoglutarate <=> (R)-2-hydroxyglutarate + acetoacetate
|
1.1.99.24
hydroxyacid-oxoacid transhydrogenase
|
–
|
|
|
BRENDA:
BR29375
KEGG:
R03225
MetaCyc:
HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN
SABIO-RK:
3051
|
|
|
|
NADP+ + acetoacetate + coenzyme_M <=> 2-oxopropyl-CoM + NADPH + CO2
|
1.8.1.5
2-oxopropyl-CoM reductase (carboxylating)
|
–
|
M
|
|
BRENDA:
BR29460
KEGG:
R05713
MetaCyc:
1.8.1.5-RXN
|
|
|
|
H2O + 4-Fumarylacetoacetate <=> H+ + fumarate + acetoacetate
|
3.7.1.2
fumarylacetoacetase
|
–
|
BMK
|
|
BRENDA:
BR29548
KEGG:
R01364
MetaCyc:
FUMARYLACETOACETASE-RXN
|
|
|
|
acetoacetate + H+ <=> acetone + CO2
|
1.8.1.5
2-oxopropyl-CoM reductase (carboxylating)
4.1.1.4
acetoacetate decarboxylase
|
–
–
|
MK
|
|
BRENDA:
BR299
KEGG:
R01366
MetaCyc:
ACETOACETATE-DECARBOXYLASE-RXN
SABIO-RK:
1568
|
|
|
|
acetone + CO2 + ATP + H2O <=> acetoacetate + AMP + phosphate + H+
|
6.4.1.6
acetone carboxylase
|
–
|
BM
|
|
BRENDA:
BR33815
KEGG:
R05735
MetaCyc:
6.4.1.6-RXN
|
|
|
|
(S)-3-hydroxy-3-methylglutaryl-CoA <=> acetoacetate + acetyl-CoA
|
4.1.3.4
hydroxymethylglutaryl-CoA lyase
|
–
|
BMK
|
|
BRENDA:
BR395;
BS416230
KEGG:
R01360
MetaCyc:
HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN
SABIO-RK:
1564
|
|
|
|
butyryl-CoA + acetoacetate <=> Butyrate + acetoacetyl-CoA
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
MK
|
|
BRENDA:
BR47924
KEGG:
R01365
MetaCyc:
2.8.3.9-RXN
SABIO-RK:
1567
|
|
|
|
(S)-5-amino-3-oxohexanoate + acetyl-CoA <=> L-3-aminobutanoyl-CoA + acetoacetate
|
2.3.1.247
3-keto-5-aminohexanoate cleavage enzyme
|
–
|
BMK
|
|
BRENDA:
BR51399
KEGG:
R10564
MetaCyc:
R125-RXN
|
|
|
|
CoA + acetoacetate + ATP <=> acetoacetyl-CoA + diphosphate + AMP
|
6.2.1.16
acetoacetate---CoA ligase
|
–
|
MK
|
|
BRENDA:
BR67
KEGG:
R01357
MetaCyc:
ACETOACETATE--COA-LIGASE-RXN
SABIO-RK:
1561
|
|
|
|
acetyl-CoA + acetoacetate <=> acetate + acetoacetyl-CoA
|
2.8.3.1
propionate CoA-transferase
2.8.3.18
succinyl-CoA:acetate CoA-transferase
2.8.3.8
acetate CoA-transferase
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
–
–
–
|
BMK
|
|
BRENDA:
BS358821
KEGG:
R01359
MetaCyc:
ACETOACETYL-COA-TRANSFER-RXN
SABIO-RK:
1563
|
|
|
|
succinyl-CoA + acetoacetate <=> succinate + acetoacetyl-CoA
|
2.8.3.18
succinyl-CoA:acetate CoA-transferase
2.8.3.5
3-oxoacid CoA-transferase
|
–
–
|
BMK
|
|
BRENDA:
BS360598
KEGG:
R00410
MetaCyc:
RXNI-2
SABIO-RK:
867
|
|
|
|
Vinylacetate + acetoacetyl-CoA <=> vinylacetyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358824
SABIO-RK:
11106
|
|
|
|
propionate + acetoacetyl-CoA <=> propionyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358825
SABIO-RK:
11107
|
|
|
|
3-Mercaptopropionate + acetoacetyl-CoA <=> 3-mercaptopropionyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358826
SABIO-RK:
11108
|
|
|
|
crotonate + acetoacetyl-CoA <=> crotonyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358827
SABIO-RK:
11109
|
|
|
|
pentanoate + acetoacetyl-CoA <=> pentanoyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358829
SABIO-RK:
11110
|
|
|
|
Isobutyrate + acetoacetyl-CoA <=> isobutyryl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358830
SABIO-RK:
11111
|
|
|
|
3-Methylvinylacetate + acetoacetyl-CoA <=> 3-methylvinylacetyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358832
SABIO-RK:
11112
|
|
|
|
beta-hydroxybutyrate + acetoacetyl-CoA <=> 3-hydroxybutyryl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358833
SABIO-RK:
11113
|
|
|
|
2-hydroxyvalerate + acetoacetyl-CoA <=> 2-hydroxypentanoyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358834
SABIO-RK:
11114
|
|
|
|
Isovalerate + acetoacetyl-CoA <=> isovaleryl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358835
SABIO-RK:
11115
|
|
|
|
Acrylate + acetoacetyl-CoA <=> acryloyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358836
SABIO-RK:
11116
|
|
|
|
Chloroacetate + acetoacetyl-CoA <=> chloroacetyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358837
SABIO-RK:
11117
|
|
|
|
4-hydroxybutyrate + acetoacetyl-CoA <=> 4-hydroxybutanoyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358838
SABIO-RK:
11118
|
|
|
|
3-hydroxypropionate + acetoacetyl-CoA <=> bithionol + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358839
SABIO-RK:
11119
|
|
|
|
DL-2-hydroxybutyrate + acetoacetyl-CoA <=> 2-hydroxybutanoyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358841
SABIO-RK:
11120
|
|
|
|
S-Acetoacetylglutathione + H2O <=> acetoacetate + glutathione
|
3.1.2.6
hydroxyacylglutathione hydrolase
|
–
|
|
|
BRENDA:
BS93046
SABIO-RK:
10436
|
|
|
|
acetoacetate <=> 3-Butynoate + H2O
|
4.2.1.27
acetylenecarboxylate hydratase
|
–
|
K
|
|
KEGG:
R01367
|
|
|
|
2-oxo-2-[4,5,7,10-tetrahydroxy-3-(3-oxobutanoyl)anthracen-2-yl]acetyl-[PKS-acp] + acetoacetate <=> 1-[4,5,7,10-tetrahydroxy-3-(3-oxobutanoyl)anthracen-2-yl]pentane-1,2,4-trione + polyketide-[acp] + CO2 + H+
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-13391
|
|
|
|
acetyl-CoA + 2-deoxy-3-dehydro-D-ribonate <=> acetoacetate + D-glyceroyl-CoA
|
2.3.1
|
–
|
M
|
|
MetaCyc:
RXN-20664
|
|
|
|
acetyl-CoA + 3-oxoadipate <=> succinyl-CoA + acetoacetate
|
2.3.1.M83
|
–
|
|
|
MetaCyc:
RXN-20775
|
|
|
|
triacetate + acetyl-CoA <=> acetoacetate + acetoacetyl-CoA
|
2.3.1.M84
|
–
|
|
|
MetaCyc:
RXN-20776
|
|
|
|
acetyl-CoA + 3-dehydrocarnitine <=> betainyl-CoA + acetoacetate
|
2.3.1.M85
|
–
|
|
|
MetaCyc:
RXN-20778
|
|
|
|
acetoacetate <=> acetoacetate
|
not assigned
|
–
|
|
|
MetaCyc:
TRANS-RXN0-281
|
|
|
|
acetone + CO2 + GTP + H2O <=> acetoacetate + GMP + phosphate
|
6.4.1.6
acetone carboxylase
|
–
|
|
|
BRENDA:
BS232557
|
|
|
|
CO2 + acetoacetate <=> acetoacetate + CO2
|
1.8.1.5
2-oxopropyl-CoM reductase (carboxylating)
|
–
|
|
|
BRENDA:
BS189490
|
|
|
|
acetoacetylcholine + H2O <=> acetoacetate + choline
|
3.1.1.8
cholinesterase
|
–
|
|
|
BRENDA:
BS73403
|
|
|
|
L-3-hydroxybutyrate + 2-oxoglutarate <=> acetoacetate + 2-oxoglutarate
|
1.1.99.24
hydroxyacid-oxoacid transhydrogenase
|
–
|
|
|
BRENDA:
BS189011
|
|
|
|
Octanoate + acetoacetyl-CoA <=> octanoyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358848
|
|
|
|
formate + acetoacetyl-CoA <=> formyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358847
|
|
|
|
N-3-oxobutanoyl-L-homoserine_lactone + H2O <=> L-homoserine_lactone + acetoacetate
|
3.5.1.97
acyl-homoserine-lactone acylase
|
–
|
|
|
BRENDA:
BS447853
|
|
|
|
4-Pentenoate + acetoacetyl-CoA <=> 4-pentenoyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358849
|
|
|
|
beta-Alanine + acetoacetate <=> malonate_semialdehyde + DL-3-aminobutyrate
|
2.6.1.18
beta-alanine---pyruvate transaminase
|
–
|
|
|
BRENDA:
BS353477
|
|
|
|
4-Maleylacetoacetate + H2O <=> acetoacetate + Maleate
|
3.7.1.2
fumarylacetoacetase
|
–
|
|
|
BRENDA:
BS385114
|
|
|
|
DL-3-aminobutyrate + 2-oxoglutarate <=> acetoacetate + L-glutamate
|
2.6.1.55
taurine---2-oxoglutarate transaminase
|
–
|
|
|
BRENDA:
BS353594
|
|
|
|
4-hydroxybutyrate + NAD+ <=> acetoacetate + NADH
|
1.1.1.30
3-hydroxybutyrate dehydrogenase
|
–
|
|
|
BRENDA:
BS383900
|
|
|
|
(R)-3-hydroxybutanoate + NADH + H+ <=> acetoacetate + NAD+
|
1.1.1.30
3-hydroxybutyrate dehydrogenase
|
–
|
|
|
BRENDA:
BS394975
|
|
|
|
beta-hydroxybutyrate + NADH + H+ <=> acetoacetate + NAD+
|
1.1.1.45
L-gulonate 3-dehydrogenase
|
–
|
|
|
BRENDA:
BS453821
|
|
|
|
L-3-hydroxybutyrate + NADH <=> acetoacetate + NAD+
|
1.1.1.45
L-gulonate 3-dehydrogenase
|
–
|
|
|
BRENDA:
BS188149
|
|
|
|
D-2-hydroxybutyrate + NAD+ <=> acetoacetate + NADH
|
1.1.1.30
3-hydroxybutyrate dehydrogenase
|
–
|
|
|
BRENDA:
BS383475
|
|
|
|
poly(3-hydroxybutanoate)n + NAD+ <=> acetoacetate + NADH + H+
|
1.1.1.30
3-hydroxybutyrate dehydrogenase
|
–
|
|
|
BRENDA:
BS406417
|
|
|
|
epsilon-Acetyl-CoA + acetoacetate <=> acetate + acetoacetyl-CoA
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358823
|
|
|
|
triacetate + H2O <=> acetoacetate + acetate
|
3.7.1.2
fumarylacetoacetase
|
–
|
|
|
BRENDA:
BS190172
|
|
|
|
L-3-hydroxybutyrate + succinate_semialdehyde <=> acetoacetate + 4-hydroxybutyrate
|
1.1.99.24
hydroxyacid-oxoacid transhydrogenase
|
–
|
|
|
BRENDA:
BS189012
|
|
|
|
acetoacetate + H2O <=> acetate
|
3.7.1.2
fumarylacetoacetase
|
–
|
|
|
BRENDA:
BS190179
|
|
|
|
S-ethyl-acetothioacetate + H2O <=> acetoacetate + 2-mercaptoethanol
|
3.1.2.32
2-aminobenzoylacetyl-CoA thioesterase
|
–
|
|
|
BRENDA:
BS437895
|
|
|
|
(R)-3-hydroxybutanoate + NADP+ <=> acetoacetate + NADPH
|
1.1.1.276
serine 3-dehydrogenase (NADP+)
1.1.1.30
3-hydroxybutyrate dehydrogenase
|
–
–
|
|
|
BRENDA:
BS355790
|
|
|
|
L-3-hydroxybutyrate + NADP+ <=> acetoacetate + NADPH
|
1.1.1.276
serine 3-dehydrogenase (NADP+)
|
–
|
|
|
BRENDA:
BS355789
|
|
|
|
3-Mercaptopropionate + acetoacetate + NADP+ <=> 3-(2-oxopropylthio)propionate + CO2 + NADPH + H+
|
1.8.1.5
2-oxopropyl-CoM reductase (carboxylating)
|
–
|
|
|
BRENDA:
BS189488
|
|
|
|
3-mercaptopropanesulfonate + acetoacetate + NADP+ <=> 2-oxopropyl-CoM + CO2 + NADPH + H+
|
1.8.1.5
2-oxopropyl-CoM reductase (carboxylating)
|
–
|
|
|
BRENDA:
BS189487
|
|
|
|
(R)-3-hydroxybutanoate + 3-acetylpyridine_adenine_dinucleotide <=> acetoacetate + reduced_acetylpyridine_adenine_dinucleotide
|
1.1.1.30
3-hydroxybutyrate dehydrogenase
|
–
|
|
|
BRENDA:
BS188035
|
|
|
|
beta-homoAla + pyruvate <=> acetoacetate + L-alanine
|
2.6.1.18
beta-alanine---pyruvate transaminase
|
–
|
|
|
BRENDA:
BS375156
|
|
|
|
DL-3-aminobutyrate + pyruvate <=> acetoacetate + L-alanine
|
2.6.1.40
(R)-3-amino-2-methylpropionate---pyruvate transaminase
|
–
|
|
|
BRENDA:
BS359153
|
|
|
|
2-Methylaspartic_acid + 2-oxoglutarate <=> CO2 + L-glutamate + acetoacetate
|
2.6.1.19
4-aminobutyrate---2-oxoglutarate transaminase
|
–
|
|
|
SABIO-RK:
7076
|
|
|
|
NAD+ + L-3-hydroxybutyrate <=> acetoacetate + NADH + H+
|
1.1.1.45
L-gulonate 3-dehydrogenase
|
–
|
|
|
SABIO-RK:
10411
|
|